Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis

S. Johnson, P. Brusasca, K. Lyashchenko, J. S. Spencer, H. G. Wiker, P. Bifani, E. Shashkina, B. Kreiswirth, M. Harboe, N. Schluger, M. Gomez, M. L. Gennaro

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

MPT53 is a secreted protein of Mycobacterium tuberculosis. Southern transfer and hybridization showed mpt53 to be conserved in the M. tuberculosis complex and to have homology with DNA from Mycobacterium avium and other nontuberculous mycobacteria. However, anti-MPT53 polyclonal antibodies detected no antigen in the culture filtrates of M. avium and other nontuberculous mycobacteria. MPT53 of M. tuberculosis induced strong, tuberculosis-specific antibody responses in guinea pigs but induced no delayed-type hypersensitivity. Involvement in immune responses during human tuberculosis was very modest.

Original languageEnglish (US)
Pages (from-to)5936-5939
Number of pages4
JournalInfection and immunity
Volume69
Issue number9
DOIs
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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