Characterizing continuous powder mixing using residence time distribution

Yijie Gao; Aditya Vanarase; Fernando Muzzio; Marianthi Ierapetritou

doi:10.1016/j.ces.2010.10.045

Characterizing continuous powder mixing using residence time distribution

Yijie Gao, Aditya Vanarase, Fernando Muzzio, Marianthi Ierapetritou

School of Engineering, Chemical & Biochemical Engineering

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

Continuous powder mixing is an efficient alternative in high volume manufacturing of powder-based products. A new method is communicated in this paper to determine the effects of different operating conditions and mixer configurations on mixing performance. The main idea of the proposed methodology is the utilization of experimental residence time distribution (RTD) measurements to (a) determine the contributions of feeding variability, powder segregation and RTD variability on output composition variance and (b) develop a predictive model of the output variance of a continuous mixer. The method is illustrated using experimental data for mixing acetaminophen and lactose in convective continuous mixer.

Original language	English (US)
Pages (from-to)	417-425
Number of pages	9
Journal	Chemical Engineering Science
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/j.ces.2010.10.045
State	Published - Feb 1 2011

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering
Industrial and Manufacturing Engineering

Keywords

Mathematical modeling
Mixing
Optimization
Particle processing
Relative standard deviation
Residence time distribution

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10.1016/j.ces.2010.10.045

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abstract = "Continuous powder mixing is an efficient alternative in high volume manufacturing of powder-based products. A new method is communicated in this paper to determine the effects of different operating conditions and mixer configurations on mixing performance. The main idea of the proposed methodology is the utilization of experimental residence time distribution (RTD) measurements to (a) determine the contributions of feeding variability, powder segregation and RTD variability on output composition variance and (b) develop a predictive model of the output variance of a continuous mixer. The method is illustrated using experimental data for mixing acetaminophen and lactose in convective continuous mixer.",

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AU - Gao, Yijie

AU - Vanarase, Aditya

AU - Muzzio, Fernando

AU - Ierapetritou, Marianthi

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Y1 - 2011/2/1

N2 - Continuous powder mixing is an efficient alternative in high volume manufacturing of powder-based products. A new method is communicated in this paper to determine the effects of different operating conditions and mixer configurations on mixing performance. The main idea of the proposed methodology is the utilization of experimental residence time distribution (RTD) measurements to (a) determine the contributions of feeding variability, powder segregation and RTD variability on output composition variance and (b) develop a predictive model of the output variance of a continuous mixer. The method is illustrated using experimental data for mixing acetaminophen and lactose in convective continuous mixer.

AB - Continuous powder mixing is an efficient alternative in high volume manufacturing of powder-based products. A new method is communicated in this paper to determine the effects of different operating conditions and mixer configurations on mixing performance. The main idea of the proposed methodology is the utilization of experimental residence time distribution (RTD) measurements to (a) determine the contributions of feeding variability, powder segregation and RTD variability on output composition variance and (b) develop a predictive model of the output variance of a continuous mixer. The method is illustrated using experimental data for mixing acetaminophen and lactose in convective continuous mixer.

KW - Mathematical modeling

KW - Mixing

KW - Optimization

KW - Particle processing

KW - Relative standard deviation

KW - Residence time distribution

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Characterizing continuous powder mixing using residence time distribution

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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