Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain

Mariagemiliana Dessi, Swetha Kodamasimham, Caroline Wood, Jay C. Sy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Convection-enhanced delivery (CED) provides a flexible platform for local delivery of drugs to brain tissue using a minimally invasive approach. Using a pressure-mediated flow, CED devices can bypass the blood–brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations and increase drug penetration and efficacy compared to systemic delivery. CED is primarily utilized in neuro-oncology applications, but may have broader applicability for treating other neural disorders, but questions of long-term biocompatibility must be addressed.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Convection
Brain
Tissue
Inflammation
Pharmaceutical Preparations
Oncology
Biocompatibility
Pressure
Equipment and Supplies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Dessi, M., Kodamasimham, S., Wood, C., & Sy, J. C. (2019). Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Dessi, Mariagemiliana ; Kodamasimham, Swetha ; Wood, Caroline ; Sy, Jay C. / Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Dessi, M, Kodamasimham, S, Wood, C & Sy, JC 2019, Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. / Dessi, Mariagemiliana; Kodamasimham, Swetha; Wood, Caroline; Sy, Jay C.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Dessi M, Kodamasimham S, Wood C, Sy JC. Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).