Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain

Mariagemiliana Dessi, Swetha Kodamasimham, Caroline Wood, Jay C. Sy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Convection-enhanced delivery (CED) provides a flexible platform for local delivery of drugs to brain tissue using a minimally invasive approach. Using a pressure-mediated flow, CED devices can bypass the blood–brain barrier in a targeted and safe manner that can achieve therapeutic drug concentrations and increase drug penetration and efficacy compared to systemic delivery. CED is primarily utilized in neuro-oncology applications, but may have broader applicability for treating other neural disorders, but questions of long-term biocompatibility must be addressed.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain'. Together they form a unique fingerprint.

  • Cite this

    Dessi, M., Kodamasimham, S., Wood, C., & Sy, J. C. (2019). Characterizing tissue deformation and inflammation due to convection enhanced delivery in the brain. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.