Charting functional and physical properties of chromatin in living cells

Eric Lam, Chongyuan Luo, Naohide Watanabe

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

With the vast transcriptome database now available, global patterns of gene expression have been mapped in various species to reveal higher order structures in the genome. Location-dependent control of gene expression has also been studied in human cell cultures and in Arabidopsis plants using well-characterized insertion and transposition cell line collections. With the added genome-wide mapping of chromatin features at a high resolution, via advanced microarray and sequencing technologies, comprehensive analysis of structure-function relationships deduced from chromatin organization and gene expression data is now feasible. This has begun to reveal micro-heterogeneity in the genome with respect to structural and functional segmentations.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume19
Issue number2
DOIs
StatePublished - Apr 2009

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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