CHEMICALLY AND ELECTRICALLY CONTROLLED MEMBRANES: SIZE SPECIFIC TRANSPORT OF FLUORESCENT SOLUTES THROUGH PMMA MEMBRANES.

Aryeh Weiss, Alan J. Grodzinsky, Martin Yarmush

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Scopus citations

Abstract

This paper focuses on the use of crosslinked, polyelectrolyte hydrogel membranes to achieve real time control of the flux of charged or neutral solutes by chemical or electrical means. For this purpose, a sensitive system capable of measuring the transmembrane flux of fluorescent solutes was developed, together with a family of fluorescent solutes of various sizes and electrical charge. Experimental results shown that large, reversible, size-specific permeability changes can be induced in crosslinked poly(methacrylic acid) (PMAA) membranes in response to changes in bath composition and to applied electric currents. The data show that permeability changes as high as a factor of 50 can be induced by altering the bath pH surrounding crosslinked PMAA membranes. Applications are in the area of actively controlled time variable membrane separation and drug delivery systems, as well as low energy analytical and preparative systems.

Original languageEnglish (US)
Title of host publicationAIChE Symposium Series
PublisherAIChE
Pages85-98
Number of pages14
Volume82
Edition250
ISBN (Print)0816903921
Publication statusPublished - Dec 1 1986
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Weiss, A., Grodzinsky, A. J., & Yarmush, M. (1986). CHEMICALLY AND ELECTRICALLY CONTROLLED MEMBRANES: SIZE SPECIFIC TRANSPORT OF FLUORESCENT SOLUTES THROUGH PMMA MEMBRANES. In AIChE Symposium Series (250 ed., Vol. 82, pp. 85-98). AIChE.