Chemistry and bioactivity of nobiletin and its metabolites

Shiming Li, Hong Wang, Limin Guo, Hui Zhao, Chi Tang Ho

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity. Major nobiletin metabolites from rodent biofluids have been successfully characterized, isolated or synthesized for the evaluation of their biological activities and subsequently revealed that nobiletin metabolites demonstrate similar efficacies or more potent anti-oxidant activity and scavenging property against free radicals and in the inhibition of inflammation and cancer growth, and the prevention of metabolic syndrome and cardiovascular diseases. This review starts with basic chemistry of nobiletin and other polymethoxyflavones, highlights their biological properties and recent findings and summarizes nobiletin's biotransformation and biological activities of the main nobiletin metabolites.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalJournal of Functional Foods
Issue number1
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


  • Bioactivity
  • Metabolite
  • Nobiletin
  • Polymethoxyflavone


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