Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors

Isabella Maita, Allyson Bazer, Kiyeon Chae, Amlaan Parida, Mikyle Mirza, Jillian Sucher, Mimi Phan, Tonia Liu, Pu Hu, Ria Soni, Troy A. Roepke, Benjamin Adam Samuels

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Corticotropin-releasing factor (CRF) in the anterior bed nucleus of the stria terminalis (aBNST) is associated with chronic stress and avoidance behavior. However, CRF + BNST neurons project to reward- and motivation-related brain regions, suggesting a potential role in motivated behavior. We used chemogenetics to selectively activate CRF+ aBNST neurons in male and female CRF-ires-Cre mice during an effort-related choice task and a concurrent choice task. In both tasks, mice were given the option either to exert effort for high value rewards or to choose freely available low value rewards. Acute chemogenetic activation of CRF+ aBNST neurons reduced barrier climbing for a high value reward in the effort-related choice task in both males and females. Furthermore, acute chemogenetic activation of CRF+ aBNST neurons also reduced effortful lever pressing in high-performing males in the concurrent choice task. These data suggest a novel role for CRF+ aBNST neurons in effort-based decision and motivation behaviors.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
JournalNeuropsychopharmacology
Volume49
Issue number2
DOIs
StatePublished - Jan 2024

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health

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