Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds

Min Hsiung Pan, Ching Shu Lai, Mei Ling Tsai, Chi Tang Ho

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and metabolic syndrome. NAFLD pathogenesis is complicated and involves oxidative stress, lipotoxicity, mitochondrial damage, insulin resistance, inflammation, and excessive dietary fat intake, which increase hepatic lipid influx and de novo lipogenesis and impair insulin signaling, thus promoting hepatic triglyceride accumulation and ultimately NAFLD. Overproduction of proinflammatory adipokines from adipose tissue also affects hepatic metabolic function. Current NAFLD therapies are limited; thus, much attention has been focused on identification of potential dietary substances from fruits, vegetables, and edible plants to provide a new strategy for NAFLD treatment. Dietary natural compounds, such as carotenoids, omega-3-PUFAs, flavonoids, isothiocyanates, terpenoids, curcumin, and resveratrol, act through a variety of mechanisms to prevent and improve NAFLD. Here, we summarize and briefly discuss the currently known targets and signaling pathways as well as the role of dietary natural compounds that interfere with NAFLD pathogenesis.

Original languageEnglish (US)
Pages (from-to)147-171
Number of pages25
JournalMolecular Nutrition and Food Research
Issue number1
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science


  • Chemoprevention
  • Dietary natural compounds
  • Nonalcoholic fatty liver disease

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