Abstract
S-Adenosylmethionine, generated enzymically in chirally pure form (S configuration at sulfur), undergoes simultaneous irreversible conversion to 5′-deoxy-5′-(methylthio)adenosine and homoserine with a rate constant of 6 × 10−6 s−1 at pH 7.5 and 37 °C and reversible conversion to an enzymically inactive stereoisomer (R configuration at sulfur) with a forward rate constant of 8 × 10−6 s−1 at pH 7.5 and 37 °C. These forms of instability require small turnover times and/or stabilization through macromolecular binding for S-adenosylmethionine, if organisms that utilize it are to avoid losses of metabolic energy.
Original language | English (US) |
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Pages (from-to) | 2828-2832 |
Number of pages | 5 |
Journal | Biochemistry |
Volume | 22 |
Issue number | 12 |
DOIs | |
State | Published - 1983 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry