Cholinergic induction of seizures in the rat prefrontal cortex

Jacqueline N. Crawley, Jill A. Stivers, Joseph V. Martin, Wallace B. Mendelson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.

Original languageEnglish (US)
Pages (from-to)2347-2354
Number of pages8
JournalLife Sciences
Issue number25
StatePublished - Jun 23 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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