Cholinergic induction of seizures in the rat prefrontal cortex

Jacqueline N. Crawley, Jill A. Stivers, Joseph Martin, Wallace B. Mendelson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Intracerebral microinjection of the cholinergic agonist, carbachol, into the medial prefrontal cortex of the rat, induced a profound behavioral syndrome consisting of repetitive, stereotyped forepaw treading in an upright posture. Electroencephalographic analysis revealed multiple bursts of sharp waves, 200-300 μV, accompanying the carbachol-elicited motor behavior. Pretreatment with intraperitoneal doses of three anticonvulsant drugs, clonazepam, diazepam, and pentobarbital, blocked the manifestation of the motor behavior. These observations suggest that activation of cholinergically innervated regions of the rat medial prefrontal cortex induces an atypical form of seizures.

Original languageEnglish (US)
Pages (from-to)2347-2354
Number of pages8
JournalLife Sciences
Volume38
Issue number25
DOIs
StatePublished - Jun 23 1986
Externally publishedYes

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Carbachol
Prefrontal Cortex
Cholinergic Agents
Rats
Seizures
Clonazepam
Cholinergic Agonists
Microinjections
Pentobarbital
Diazepam
Posture
Anticonvulsants
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Crawley, Jacqueline N. ; Stivers, Jill A. ; Martin, Joseph ; Mendelson, Wallace B. / Cholinergic induction of seizures in the rat prefrontal cortex. In: Life Sciences. 1986 ; Vol. 38, No. 25. pp. 2347-2354.
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Cholinergic induction of seizures in the rat prefrontal cortex. / Crawley, Jacqueline N.; Stivers, Jill A.; Martin, Joseph; Mendelson, Wallace B.

In: Life Sciences, Vol. 38, No. 25, 23.06.1986, p. 2347-2354.

Research output: Contribution to journalArticle

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