Chronic haloperidol inactivates brain noradrenergic neurons

Timothy G. Dinan, Gary Aston-Jones

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalBrain research
Volume325
Issue number1-2
DOIs
StatePublished - Jan 28 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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