Chronic haloperidol inactivates brain noradrenergic neurons

Timothy G. Dinan; Gary Aston-Jones

doi:10.1016/0006-8993(85)90346-4

Chronic haloperidol inactivates brain noradrenergic neurons

Timothy G. Dinan, Gary Aston-Jones

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

Original language	English (US)
Pages (from-to)	385-388
Number of pages	4
Journal	Brain research
Volume	325
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)90346-4
State	Published - Jan 28 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)90346-4

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title = "Chronic haloperidol inactivates brain noradrenergic neurons",

abstract = "Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.",

author = "Dinan, {Timothy G.} and Gary Aston-Jones",

note = "Funding Information: This work was supportedb y NINCDS Grant NS 19360,B RSG Grant S07RR7149-09a,n dSUNY Re-searchF oundationG rant0 140-03H. aloperidowl asa gift of McNeil PharmaceuticCaol .",

year = "1985",

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doi = "10.1016/0006-8993(85)90346-4",

language = "English (US)",

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T1 - Chronic haloperidol inactivates brain noradrenergic neurons

AU - Dinan, Timothy G.

AU - Aston-Jones, Gary

N1 - Funding Information: This work was supportedb y NINCDS Grant NS 19360,B RSG Grant S07RR7149-09a,n dSUNY Re-searchF oundationG rant0 140-03H. aloperidowl asa gift of McNeil PharmaceuticCaol .

PY - 1985/1/28

Y1 - 1985/1/28

N2 - Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

AB - Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

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ER -

Chronic haloperidol inactivates brain noradrenergic neurons

Abstract

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