Abstract
Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.
Original language | English (US) |
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Pages (from-to) | 385-388 |
Number of pages | 4 |
Journal | Brain research |
Volume | 325 |
Issue number | 1-2 |
DOIs | |
State | Published - Jan 28 1985 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology