Chronic haloperidol inactivates brain noradrenergic neurons

Timothy G. Dinan; Gary Aston-Jones

doi:10.1016/0006-8993(85)90346-4

Chronic haloperidol inactivates brain noradrenergic neurons

Timothy G. Dinan, Gary Aston-Jones

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

Original language	English (US)
Pages (from-to)	385-388
Number of pages	4
Journal	Brain research
Volume	325
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)90346-4
State	Published - Jan 28 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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AU - Aston-Jones, Gary

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AB - Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC control cells. These results reveal that haloperidol has profound effects on LC neurons that develop with prolonged administration, indicating a possible role of brain noradrenergic systems in clinical effects (and possible side-effects) of this neuroleptic.

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