TY - JOUR
T1 - Chronic Rhinosinusitis Is an Independent Risk Factor for OSA in World Trade Center Responders
AU - Sunderram, Jag
AU - Weintraub, Michael
AU - Black, Kathleen
AU - Alimokhtari, Shahnaz
AU - Twumasi, Akosua
AU - Sanders, Haley
AU - Udasin, Iris
AU - Harrison, Denise
AU - Chitkara, Nishay
AU - de la Hoz, Rafael E.
AU - Lu, Shou En
AU - Rapoport, David M.
AU - Ayappa, Indu
N1 - Funding Information:
FUNDING/SUPPORT : This study was funded by the National Institute for Occupational Safety and Health / Centers for Disease Control and Prevention [Grants U01OH010415, U10OH008232 (DCC), 200-2011-39356 (Mount Sinai CCE), 200-2011-39385 (Rutgers CCE), 200-2011-39384 (NYU CCE)]; and a National Institutes of Health K24 grant [Grant HL109156 ].
Funding Information:
FUNDING/SUPPORT: This study was funded by the National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention [Grants U01OH010415, U10OH008232 (DCC), 200-2011-39356 (Mount Sinai CCE), 200-2011-39385 (Rutgers CCE), 200-2011-39384 (NYU CCE)]; and a National Institutes of Health K24 grant [Grant HL109156].Financial/nonfinancial disclosures: The authors have reported to CHEST the following: J. S., I. A., K. B., I. U., D. M. R., S.-E. L., N. C., D. H., and R. E. H. report grants from CDC/NIOSH during the conduct of the study. D. M. R. and I. A. report grants, personal fees, nonfinancial support, and other from Fisher Paykel Healthcare outside the submitted work. D. M. R. and I. A. also have patents for modifications of CPAP that result in royalties paid through New York University. None declared (M. W., S. A., A. T., H. S.).
Publisher Copyright:
© 2018 American College of Chest Physicians
PY - 2019/2
Y1 - 2019/2
N2 - Background: Many respiratory conditions have been attributed to toxic dust and fume exposure in World Trade Center (WTC) rescue and recovery workers, who frequently report symptoms of OSA. We examined the prevalence of new-onset OSA and tested if the prevalence and severity of OSA are related to the presence of chronic rhinosinusitis (CRS). Methods: A total of 601 subjects (83% men; age, 33-87 years; BMI, 29.9 ± 5.5 kg/m 2 ) enrolled in the WTC Health Program, excluding those with significant pre-September 11, 2001, snoring or prior CRS, underwent two nights of home sleep testing. OSA was defined as Apnea Hypopnea Index 4% ≥ 5 events/h or respiratory disturbance index of ≥ 15 events/h. CRS was assessed using nasal symptom questionnaires. Results: The prevalence of OSA was 75% (25% no OSA, 46% mild OSA, 19% moderate OSA, and 10% severe OSA), and the prevalence of CRS was 43.5%. Compared with no CRS, new and worsening CRS was a significant risk factor for OSA with an OR of 1.80 (95% CI, 1.18-2.73; P =.006) unadjusted and 1.76 (95% CI, 1.08-2.88; P =.02) after adjustment for age, BMI, sex, gastroesophageal reflux disorder, and alcohol use. Conclusions: The high prevalence of OSA in WTC responders was not explained fully by obesity and sex. Possible mechanisms for the elevated risk of OSA in subjects with CRS include increased upper airway inflammation and/or elevated nasal/upper airway resistance, but these need confirmation.
AB - Background: Many respiratory conditions have been attributed to toxic dust and fume exposure in World Trade Center (WTC) rescue and recovery workers, who frequently report symptoms of OSA. We examined the prevalence of new-onset OSA and tested if the prevalence and severity of OSA are related to the presence of chronic rhinosinusitis (CRS). Methods: A total of 601 subjects (83% men; age, 33-87 years; BMI, 29.9 ± 5.5 kg/m 2 ) enrolled in the WTC Health Program, excluding those with significant pre-September 11, 2001, snoring or prior CRS, underwent two nights of home sleep testing. OSA was defined as Apnea Hypopnea Index 4% ≥ 5 events/h or respiratory disturbance index of ≥ 15 events/h. CRS was assessed using nasal symptom questionnaires. Results: The prevalence of OSA was 75% (25% no OSA, 46% mild OSA, 19% moderate OSA, and 10% severe OSA), and the prevalence of CRS was 43.5%. Compared with no CRS, new and worsening CRS was a significant risk factor for OSA with an OR of 1.80 (95% CI, 1.18-2.73; P =.006) unadjusted and 1.76 (95% CI, 1.08-2.88; P =.02) after adjustment for age, BMI, sex, gastroesophageal reflux disorder, and alcohol use. Conclusions: The high prevalence of OSA in WTC responders was not explained fully by obesity and sex. Possible mechanisms for the elevated risk of OSA in subjects with CRS include increased upper airway inflammation and/or elevated nasal/upper airway resistance, but these need confirmation.
KW - OSA
KW - WTC exposure
KW - chronic rhinosinusitis
KW - nasal symptoms
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U2 - 10.1016/j.chest.2018.10.015
DO - 10.1016/j.chest.2018.10.015
M3 - Article
C2 - 30739642
AN - SCOPUS:85059153090
VL - 155
SP - 375
EP - 383
JO - Diseases of the chest
JF - Diseases of the chest
SN - 0012-3692
IS - 2
ER -