Cigarette smoking reduces human salivary eicosanoids

C. Y. Wu-Wang, S. L. Wang, C. Lim, M. Milles, A. Slomiany, B. L. Slomiany

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The effect of cigarette smoking on salivary eicosanoid levels was investigated in 10 smoker and 10 non-smoker volunteers. The smokers consumed an average of 20 cigarettes/day for the past 5 years or longer. The smoking status was validated by salivary cotinine level. Eicosanoids were extracted from saliva with ethanol, and the radioimmunoassay was performed to determine the concentrations of four major eicosanoids, i.e. prostaglandin E2 (PGE2), PGF, 6-sulphidopeptide-containing leukotrienes (LTs) and 12-hydroxyeicosatetraenoic acid (12-HETE). The levels of PGE2, PGF, and LTs were significantly lower in the saliva of smokers as compared to that of the non-smokers (1.74 ± 0.32 vs 2.41 ± 0.64, p=0.006; 0.36 ± 0.12 vs 0.54 ± 0.18, p=0.04; 2.24 ± 0.96 vs 4.92 ± 1.29, p=0.006; mean ± SD, ng/ml saliva). No significant differences were found in the levels of 12-HETE between the two groups. The results suggest that cigarette smoking reduces the concentrations of both the cyclooxygenase and 5-lipoxygenase products in saliva.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Issue number2
StatePublished - Oct 1992

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology


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