Classification and Epidemiologic Aspects of Acute Liver Failure

Daniel Pievsky, Neil Rustgi, Nikolaos T. Pyrsopoulos

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Acute liver failure is a rare condition with high short-term morbidity and mortality. The most widely accepted definition is an abnormality in coagulation with any degree of encephalopathy in a patient without cirrhosis and an illness duration of less than 26 weeks. Multiple classifications systems are currently in use to help categorize the condition. This article reviews the most commonly used systems. The epidemiologic aspects of the disease are also reviewed, including incidence, prevalence, demographics, geographic distribution, and racial and cultural factors and are discussed for the various subtypes of acute liver failure.

Original languageEnglish (US)
Pages (from-to)229-241
Number of pages13
JournalClinics in Liver Disease
Issue number2
StatePublished - May 2018

All Science Journal Classification (ASJC) codes

  • Hepatology


  • Acute liver failure
  • Classification
  • Epidemiology
  • Fulminant liver failure
  • Race

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