Clindamycin in the Oral Treatment of Putative Anaerobic Pneumonias

Purnendu Sen, Flor Tecson, Rajendra Kapila, Donald B. Louria

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Thirty patients with presumed anaerobic pleuropulmonary infection were treated with clindamycin hydrochloride. Diagnoses of anaerobic infections were made primarily on clinical evidence, including history of aspiration, fetid sputum, and x-ray findings of pulmonary infiltrates, frequently with cavity formation. All patients were treated with clindamycin hydrochloride by mouth for 10 to 28 days in a dosage of 150 to 300 mg four times a day. Twenty-six patients showed a favorable response, although 6 also required closed thoracotomy with tube drainage of the pleural space. No serious side effects were encountered, although one patient developed transient neutropenia, and another showed elevation of hepatic enzyme levels. There were no cases of clinical superinfection, and only four patients acquired Gram-negative enteric pathogens in the sputum in low titers. Clindamycin given orally thus appears to be an effective initial antibiotic in the treatment of anaerobic pneumonias.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalArchives of Internal Medicine
Volume134
Issue number1
DOIs
StatePublished - Jul 1974

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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