Clinical and pharmacokinetic evaluation of moxalactam in infants and children

Mathew Varghese, Abdul J. Khan, George Quaye, Urmila Patel, Kusum Kumar, Hugh Evans

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Abstract

Moxalactam, a new beta-lactam antibiotic was evaluated in the treatment of 21 pediatric patients including 16 with clinical and radiological evidence of pneumonia and 5 with urinary tract infection (UTI). Clinical and radiological resolution of pneumonia occurred in all. Bacteriological efficacy in pneumonia, however, was assessed in only 1 patient whose blood culture grew H. influenzae type b. In patients with UTI, the therapy was successful, bacteriologically as well as clinically. The only side effects observed were mild transient elevation of SGOT and alkaline phosphatase in 6 cases. The peak and trough levels of the drug were manyfold higher than the known minimum inhibitory concentrations of common pathogens. The mean t½ projected of 95 and 124 min with intravenous and intramuscular route, respectively, were similar to those reported in adults.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalChemotherapy
Volume28
Issue number6
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)
  • Infectious Diseases

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