Clinical pharmacology of methotrexate

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Methotrexate (MTX), a potent folate antagonist by virtue of its ability to inhibit the enzyme dihydrofolate reductase [1], continues to be a useful cancer chemotherapeutic agent [2]. Information not only on its mechanism of action, but also its pharmacology has led to improved dosage schedules of this drug alone and in combination. The use of high (gm) doses of MTX followed by leucovorin “rescue” has required close attention to the blood levels of this drug and has stimulated further studies of its clinical pharmacology, especially of high‐dose regimens. This review summarizes the present status of the clinical pharmacology of MTX.

Original languageEnglish (US)
Pages (from-to)401-411
Number of pages11
JournalMedical and Pediatric Oncology
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1982

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Clinical pharmacology of methotrexate'. Together they form a unique fingerprint.

Cite this