TY - JOUR
T1 - Clinical Safety of Lidocaine in Patients With Cocaine-Associated Myocardial Infarction
AU - Shih, Richard D.
AU - Hollander, Judd E.
AU - Burstein, Jonathan L.
AU - Nelson, Lewis S.
AU - Hoffmann, Robert S.
AU - Quick, Annette M.
PY - 1995/12
Y1 - 1995/12
N2 - Study objective: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI). Design: A retrospective, multicenter study. Setting: Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years). Participants: Patients with cocaine-associated MI who received lidocaine in the emergency department. Results: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%). Conclusion: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity. [Shih RD, Hollander JE, Burstein JL, Nelson LS, Hoffman RS, Quick AM, and the Cocaine-Associated Myocardial Infarction Study Group: Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Ann Emerg Med December 1995;26:702-706.].
AB - Study objective: To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI). Design: A retrospective, multicenter study. Setting: Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years). Participants: Patients with cocaine-associated MI who received lidocaine in the emergency department. Results: Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%). Conclusion: Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity. [Shih RD, Hollander JE, Burstein JL, Nelson LS, Hoffman RS, Quick AM, and the Cocaine-Associated Myocardial Infarction Study Group: Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Ann Emerg Med December 1995;26:702-706.].
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U2 - 10.1016/S0196-0644(95)70041-2
DO - 10.1016/S0196-0644(95)70041-2
M3 - Article
C2 - 7492040
AN - SCOPUS:0028824382
SN - 0196-0644
VL - 26
SP - 702
EP - 706
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
IS - 6
ER -