Clinical staging: A necessary step in the development of improved animal models of mood disturbance?

Frederick Rohan Walker, Morgan H. James, Ian B. Hickie, Patrick D. McGorry

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Abstract Recently, it has been suggested that the clinical staging approach be considered a serious alternative framework for conceptualising mood related psychopathology. The fundamental difference between clinical staging and the now dominant categorical diagnostic framework is that the entire illness trajectory becomes relevant, as opposed to simply the end-stage. The concept of disease trajectory has significant implications for animal models of psychopathology, and particularly for animal models of depression. This article will introduce and discuss the implications of the clinical staging approach for those undertaking research using animal models of mood disturbance.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Volume17
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Keywords

  • Animal models of depression
  • Clinical staging
  • Depression
  • Mood disorders

Fingerprint

Dive into the research topics of 'Clinical staging: A necessary step in the development of improved animal models of mood disturbance?'. Together they form a unique fingerprint.

Cite this