Clinicopathologic characteristics of laryngeal chondrosarcoma: An analysis of the National Cancer Database

Janet O. Adeola, Jimmy S. Patel, Roman Povolotskiy, Gregory L. Barinsky, Jordon G. Grube, Wayne D. Hsueh, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: Laryngeal Chondrosarcoma (LC) is a rare malignancy with limited studies documenting its clinicopathologic characteristics and treatment options. This study reports demographic and clinical determinants of outcomes for this rare tumor. Methods: The National Cancer Database (NCDB) was queried for cases of LC reported from 2004–2016. 274 cases that met inclusion criteria were analyzed for demographic and clinicopathologic characteristics. Kaplan-Meier (KM) and Cox proportional hazard analyses were conducted to identify variables that impacted the overall survival of these patients. Results: LC was found to be more common in males (74.8%). The mean age of patients was 61.8 years and 92.3% of the patients were white. 91.3% of patients were treated with only surgical resection, most commonly: partial laryngectomy (31.6%), total laryngectomy (25.7%), and local resection (22.4%). 98.8% of patients had no evidence of nodal disease and 99.6% of patients did not have distant metastasis at presentation. KM analysis revealed a 5-year overall survival (5YOS) of 89.0%. Age, insurance status, facility type, and surgery type were significant predictors of 5YOS (p<0.05). On Cox Proportional Hazard analysis, private insurance significantly improved survival (HR 0.21; p = 0.048) while increasing age was a poor prognostic indicator (HR 1.10; p = 0.004). Conclusion: The majority of LC patients present with no nodal involvement or distant metastasis at diagnosis, and overall this tumor has a favorable prognosis. Increasing age was found to be a poor prognostic factor while private insurance status was associated with improved survival.

Original languageEnglish (US)
Pages (from-to)956-962
Number of pages7
JournalAuris Nasus Larynx
Issue number5
StatePublished - Oct 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology


  • Laryngeal cancer
  • Laryngeal chondrosarcoma
  • Laryngeal malignancy
  • Laryngeal tumor
  • NCDB


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