CLOCK leaves its mark on histones

William J. Belden, Jennifer J. Loros, Jay C. Dunlap

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations


Transcriptional regulation of circadian rhythms in mammals involves a negative-feedback loop whereby a CLOCK-BMAL1 complex activates transcription of the genes encoding the proteins PER1 (Period 1), PER2, CRY1 (Cryptochrome 1) and CRY2, which feed back to inhibit the activity of CLOCK-BMAL1. It is becoming evident that chromatin remodeling has a crucial role in the transcriptional regulation of genes governing circadian rhythms. This is highlighted in a recent report that shows that CLOCK has histone acetyltransferase activity, thus, demonstrating that molecular components of the biological clock can themselves catalyze chromatin modifications.

Original languageEnglish (US)
Pages (from-to)610-613
Number of pages4
JournalTrends in Biochemical Sciences
Issue number11
StatePublished - Nov 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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