Cloning and embryonic expression ofXenopus laevis GAP-43 (XGAP-43)

Daniel H. Shain, Dawit T. Haile, Todd A. Verrastro, Mauricio X. Zuber

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Xenopus laevis GAP-43 (XGAP-43) is highly related to other vertebrate GAP-43 proteins in its N-terminal region which contains a membrane-targeting sequence, serine phosphorylation site, and calmodulin binding domain. Unlike other species examined, however, there appear to be two GAP-43-class genes inX. laevis which resulted from the genome duplication inXenopus approximately 30 million years ago. During embryogenesis, XGAP-43 is expressed in a complex spatiotemporal pattern that is consistent with its putative role in neuronal growth and development.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalBrain research
Issue number1-2
StatePublished - Oct 30 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


  • B-50
  • Expression
  • GAP-43
  • Neuromodulin
  • Phylogeny
  • Tetraploidy
  • Xenopus laevis

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