Xenopus laevis GAP-43 (XGAP-43) is highly related to other vertebrate GAP-43 proteins in its N-terminal region which contains a membrane-targeting sequence, serine phosphorylation site, and calmodulin binding domain. Unlike other species examined, however, there appear to be two GAP-43-class genes inX. laevis which resulted from the genome duplication inXenopus approximately 30 million years ago. During embryogenesis, XGAP-43 is expressed in a complex spatiotemporal pattern that is consistent with its putative role in neuronal growth and development.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Clinical Neurology
- Developmental Biology
- Xenopus laevis