Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Alex M. Chen; Min Zhang; Dongguang Wei; Dirk Stueber; Oleh Taratula; Tamara Minko; Huixin He

doi:10.1002/smll.200900621

Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Alex M. Chen, Min Zhang, Dongguang Wei, Dirk Stueber, Oleh Taratula, Tamara Minko, Huixin He

Research output: Contribution to journal › Article › peer-review

580 Scopus citations

Abstract

Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image).

Original language	English (US)
Pages (from-to)	2673-2677
Number of pages	5
Journal	Small
Volume	5
Issue number	23
DOIs	https://doi.org/10.1002/smll.200900621
State	Published - Dec 4 2009

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

Keywords

Apoptosis
Co-delivery
Gene expression
Nanotechnology
Simultaneous delivery of drug and siRNA

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10.1002/smll.200900621

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title = "Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells",

abstract = "Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image).",

keywords = "Apoptosis, Co-delivery, Gene expression, Nanotechnology, Simultaneous delivery of drug and siRNA",

author = "Chen, {Alex M.} and Min Zhang and Dongguang Wei and Dirk Stueber and Oleh Taratula and Tamara Minko and Huixin He",

year = "2009",

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doi = "10.1002/smll.200900621",

language = "English (US)",

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AU - Chen, Alex M.

AU - Zhang, Min

AU - Wei, Dongguang

AU - Stueber, Dirk

AU - Taratula, Oleh

AU - Minko, Tamara

AU - He, Huixin

PY - 2009/12/4

Y1 - 2009/12/4

N2 - Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image).

AB - Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image).

KW - Apoptosis

KW - Co-delivery

KW - Gene expression

KW - Nanotechnology

KW - Simultaneous delivery of drug and siRNA

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DO - 10.1002/smll.200900621

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Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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