Co-delivery of Doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells

Alex M. Chen, Min Zhang, Dongguang Wei, Dirk Stueber, Oleh Taratula, Tamara Minko, Huixin He

Research output: Contribution to journalArticlepeer-review

580 Scopus citations

Abstract

Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image).

Original languageEnglish (US)
Pages (from-to)2673-2677
Number of pages5
JournalSmall
Volume5
Issue number23
DOIs
StatePublished - Dec 4 2009

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Keywords

  • Apoptosis
  • Co-delivery
  • Gene expression
  • Nanotechnology
  • Simultaneous delivery of drug and siRNA

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