Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

Rafael Benoliel, Masako Tanaka, Robert M. Caudle, Michael J. Iadarola

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - Sep 15 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


  • Glutamate, Pain
  • Intermediolateral nucleus
  • Motorneurons
  • Onuf's nucleus
  • Parasympathetic nervous system
  • Receptor co-localization
  • Sympathetic nervous system


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