Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

Rafael Benoliel; Masako Tanaka; Robert M. Caudle; Michael J. Iadarola

doi:10.1016/S0304-3940(00)01337-9

Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

Rafael Benoliel, Masako Tanaka, Robert M. Caudle, Michael J. Iadarola

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	61-64
Number of pages	4
Journal	Neuroscience Letters
Volume	291
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01337-9
State	Published - Sep 15 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Keywords

Glutamate, Pain
Intermediolateral nucleus
Motorneurons
Onuf's nucleus
Parasympathetic nervous system
Receptor co-localization
Sympathetic nervous system

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10.1016/S0304-3940(00)01337-9

Cite this

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title = "Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord",

abstract = "Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.",

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T1 - Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

AU - Benoliel, Rafael

AU - Tanaka, Masako

AU - Caudle, Robert M.

AU - Iadarola, Michael J.

PY - 2000/9/15

Y1 - 2000/9/15

N2 - Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.

AB - Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.

KW - Glutamate, Pain

KW - Intermediolateral nucleus

KW - Motorneurons

KW - Onuf's nucleus

KW - Parasympathetic nervous system

KW - Receptor co-localization

KW - Sympathetic nervous system

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Co-localization of N-methyl-D-aspartate receptors and substance P (neurokinin-1) receptors in rat spinal cord

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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