Abstract
Glutamate, substance P (SP), and their receptors have been implicated in the initiation and maintenance of persistent pain through an interaction at second order spinal cord neurons. Employing well-characterized antibodies to the SP receptor and the N-methyl-D-aspartate receptor (NR1 subunit, splice variant missing exon 22), we demonstrate co-localization of these receptors on second order neurons at cervical, thoracic, lumbar, and sacral spinal cord levels. The co-localization was marked in lamina I of the dorsal horn at all levels and in the intermediolateral nucleus of the thoraco-lumbar spinal cord nuclei associated with autonomic function. (C) 2000 Elsevier Science Ireland Ltd.
Original language | English (US) |
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Pages (from-to) | 61-64 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 291 |
Issue number | 2 |
DOIs | |
State | Published - Sep 15 2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience
Keywords
- Glutamate, Pain
- Intermediolateral nucleus
- Motorneurons
- Onuf's nucleus
- Parasympathetic nervous system
- Receptor co-localization
- Sympathetic nervous system