Cocaine blocks the dopamine depletion induced by MPTP

R. A. Mayer; M. F. Jarvis; G. C. Wagner

Cocaine blocks the dopamine depletion induced by MPTP

R. A. Mayer, M. F. Jarvis, G. C. Wagner

Research output: Contribution to journal › Article › peer-review

Abstract

The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice causes a long-lasting depletion of striatal dopamine. The concomitant administration of a dopamine uptake blocker, cocaine, protected the mice from this MPTP-induced dopamine depletion. These observations are discussed in reference to the mechanism through which MPTP enters domainergic neurons as well as species differences in the sensitivity of the serotonergic system to the toxic effects of MPTP.

Original language	English (US)
Pages (from-to)	145-148
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	49
Issue number	1
State	Published - 1985

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{a684c1fdc8584bd49251c8c491fab292,

title = "Cocaine blocks the dopamine depletion induced by MPTP",

abstract = "The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice causes a long-lasting depletion of striatal dopamine. The concomitant administration of a dopamine uptake blocker, cocaine, protected the mice from this MPTP-induced dopamine depletion. These observations are discussed in reference to the mechanism through which MPTP enters domainergic neurons as well as species differences in the sensitivity of the serotonergic system to the toxic effects of MPTP.",

author = "Mayer, {R. A.} and Jarvis, {M. F.} and Wagner, {G. C.}",

year = "1985",

language = "English (US)",

volume = "49",

pages = "145--148",

journal = "Research Communications in Chemical Pathology and Pharmacology",

issn = "0034-5164",

publisher = "PJD Publications Ltd",

number = "1",

}

TY - JOUR

T1 - Cocaine blocks the dopamine depletion induced by MPTP

AU - Mayer, R. A.

AU - Jarvis, M. F.

AU - Wagner, G. C.

PY - 1985

Y1 - 1985

N2 - The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice causes a long-lasting depletion of striatal dopamine. The concomitant administration of a dopamine uptake blocker, cocaine, protected the mice from this MPTP-induced dopamine depletion. These observations are discussed in reference to the mechanism through which MPTP enters domainergic neurons as well as species differences in the sensitivity of the serotonergic system to the toxic effects of MPTP.

AB - The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice causes a long-lasting depletion of striatal dopamine. The concomitant administration of a dopamine uptake blocker, cocaine, protected the mice from this MPTP-induced dopamine depletion. These observations are discussed in reference to the mechanism through which MPTP enters domainergic neurons as well as species differences in the sensitivity of the serotonergic system to the toxic effects of MPTP.

UR - http://www.scopus.com/inward/record.url?scp=0021885682&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021885682&partnerID=8YFLogxK

M3 - Article

C2 - 3875884

AN - SCOPUS:0021885682

SN - 0034-5164

VL - 49

SP - 145

EP - 148

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 1

ER -

Cocaine blocks the dopamine depletion induced by MPTP

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this