Cocaine blocks the dopamine depletion induced by MPTP

R. A. Mayer, M. F. Jarvis, G. C. Wagner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice causes a long-lasting depletion of striatal dopamine. The concomitant administration of a dopamine uptake blocker, cocaine, protected the mice from this MPTP-induced dopamine depletion. These observations are discussed in reference to the mechanism through which MPTP enters domainergic neurons as well as species differences in the sensitivity of the serotonergic system to the toxic effects of MPTP.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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