Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function

Maria S. Brenz Verca, David A.J. Widmer, George Wagner, Jean Luc Dreyer

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

CD81, a tetraspanin transmembrane protein involved in cell adhesion, was found by differential display to be up-regulated in the nucleus accumbens of rat brain following acute cocaine treatment (four injections of 30 mg/kg every 2 h followed by 24 h withdrawal). Cocaine-induced expression of CD81 in adult rat brain was confirmed by quantitative real-time RT-PCR. Its expression in neurons and its function in the brain are unknown. In situ hybridization shows a neuron-specific expression pattern in brain regions functionally related to the regulation of cardiovascular function and fluid homeostasis. CD81 displays codistribution to galanin and, to a lesser extent, to vasopressin. These findings add to data that suggest a connection between the brain reward pathway and the centers regulating endocrine and autonomic functions, in relation to neurochemical, behavioral, and somatic consequences of drug abuse.

Original languageEnglish (US)
Pages (from-to)303-316
Number of pages14
JournalMolecular and Cellular Neuroscience
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2001

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Fingerprint Dive into the research topics of 'Cocaine-induced expression of the tetraspanin CD81 and its relation to hypothalamic function'. Together they form a unique fingerprint.

  • Cite this