Coidentification of mcr-4.3 and blaNDM-1 in a clinical enterobacter cloacae isolate from China

Bhakti Chavda, Jingnan Lv, Mengyun Hou, Kalyan D. Chavda, Barry N. Kreiswirth, Youjun Feng, Liang Chen, Fangyou Yu

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28 Scopus citations

Abstract

We describe the first report of a clinical colistin-resistant ST84 Enterobacter cloacae isolate coharboring mcr-4.3 (previously named mcr-4.2) and blaNDM-1 from a patient in China. The blaNDM-1-harboring IncX3 plasmid and the novel mcr-4.3-harboring ColE plasmid were completely sequenced. Although this isolate showed a high level of resistance to colistin, mcr-4.3 plasmid transformation, gene subcloning, susceptibility testing, and lipid A matrix-assisted laser desorption ionization mass spectrometry analysis indicated that mcr-4.3 itself does not confer resistance to colistin.

Original languageEnglish (US)
Article numbere00649
JournalAntimicrobial agents and chemotherapy
Volume62
Issue number10
DOIs
StatePublished - Oct 2018

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Keywords

  • Carbapenem resistant
  • Colistin
  • Mcr-4
  • NDM-1
  • Plasmid

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