Collagen-based wound dressing: Effects of hyaluronic acid and firponectin on wound healing

Charles J. Doillon, Frederick H. Silver

Research output: Contribution to journalArticlepeer-review

196 Scopus citations


Our previous studies have shown that a collagen-based wound dressing induces the spatial deposition of wound tissue. This study was conducted to determine the effects of hyaluronic acid and fibronectin on wound healing. These macromolecules play an important role in wound healing, embryonic development and cellular migration in vitro. The effects of the addition of varying levels of fibronectin and hyaluronate to a collagen sponge were studied. Low levels of both hyaluronate and fibronectin modifiied the structure of the implant, and resulted in increased chemoattraction, replication and collagen deposition in an in vivo wound healing model.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
Issue number1
StatePublished - Jan 1986

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


  • Wound dressing
  • collagen
  • fibronectin
  • hyaluronic acid
  • wound healing


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