Connective tissues are composed of fibrous and nonfibrous components. Collagen and elastic fibers are the fibrous components; other composite macromolecules termed proteoglycans (PG) and glycosaminoglycans (GAG) constitute the nonfibrous components. Previous studies indicated that dextran sulfate, an analog of the sugar component of PG, inhibits type-I collagen fiber formation and decreases fiber organization. Experiments were conducted to study the effect of GAGs on mechanical and physicochemical properties of reconstituted type I collagen fibers for the design of collagen-based implants.
|Original language||English (US)|
|Number of pages||2|
|State||Published - 1987|
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