Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

Yanyin Yang; Durgadas Bolikal; Matthew L. Becker; Joachim Kohn; Diana N. Zeiger; Carl G. Simon

doi:10.1002/adma.200702088

Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

Yanyin Yang, Durgadas Bolikal, Matthew L. Becker, Joachim Kohn, Diana N. Zeiger, Carl G. Simon

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

A method for fabricating combinatorial libraries of polymer scaffolds was proposed for screening cell-biomaterial interactions in a three-dimensional (3D) format. The libraries used were of varying composition of two amorphous, biodegradable, biocompatible, tyrosine-derived polycarbonates, namely, pDTEc [poly(desaminotyrosyl-tyrosine ethyl ester carbonate)] and pDTOc [poly(desaminotyrosyl-tyrosine octyl ester carbonate)]. The fabrication of combinatorial libraries was made in polypropylene 96-well plates using a two-syirnge pump system, yielding arrays of salt-leached, macroporous scaffolds of varying compositions of pDTEc and pDTOc, having different physiochemical properties. The designed libraries were ideal for screening cell response so that scaffold formulations that promote or suppress cellular activity can be identified rapidly.

Original language	English (US)
Pages (from-to)	2037-2043
Number of pages	7
Journal	Advanced Materials
Volume	20
Issue number	11
DOIs	https://doi.org/10.1002/adma.200702088
State	Published - Jun 4 2008

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200702088

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abstract = "A method for fabricating combinatorial libraries of polymer scaffolds was proposed for screening cell-biomaterial interactions in a three-dimensional (3D) format. The libraries used were of varying composition of two amorphous, biodegradable, biocompatible, tyrosine-derived polycarbonates, namely, pDTEc [poly(desaminotyrosyl-tyrosine ethyl ester carbonate)] and pDTOc [poly(desaminotyrosyl-tyrosine octyl ester carbonate)]. The fabrication of combinatorial libraries was made in polypropylene 96-well plates using a two-syirnge pump system, yielding arrays of salt-leached, macroporous scaffolds of varying compositions of pDTEc and pDTOc, having different physiochemical properties. The designed libraries were ideal for screening cell response so that scaffold formulations that promote or suppress cellular activity can be identified rapidly.",

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AU - Yang, Yanyin

AU - Bolikal, Durgadas

AU - Becker, Matthew L.

AU - Kohn, Joachim

AU - Zeiger, Diana N.

AU - Simon, Carl G.

PY - 2008/6/4

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Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

Abstract

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