Combined effect of mercuric ion and silver ion on the clotting time of blood

Uma R. Phatak, David Kristol, Rohit R. Arora, Charles Spillert

Research output: Contribution to conferencePaper

Abstract

Mercuric ion (Hg2+) has been shown to have a procoagulant effect on citrated whole blood through its excitation of the extrinsic pathway. Silver ion (Ag+) affects the intrinsic pathway of blood coagulation also producing a shortened clotting time. This in vitro study involved mixing citrated whole blood (CWB) with mercuric nitrate Hg(NO3)2, silver nitrate AgNO3, and the combination of the two. The eight samples were incubated for ten minutes at 37°C and were analyzed by an Amelung KC 4A clot detector. The results show that the combination of Ag + and Hg2+ significantly reduces the clotting time (p < .002).

Original languageEnglish (US)
Number of pages1
StatePublished - Aug 22 2003
EventProceedings of the IEEE 29th Annual Northeast Bioengineering Conference - Newark, NJ, United States
Duration: Mar 22 2003Mar 23 2003

Other

OtherProceedings of the IEEE 29th Annual Northeast Bioengineering Conference
CountryUnited States
CityNewark, NJ
Period3/22/033/23/03

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All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Phatak, U. R., Kristol, D., Arora, R. R., & Spillert, C. (2003). Combined effect of mercuric ion and silver ion on the clotting time of blood. Paper presented at Proceedings of the IEEE 29th Annual Northeast Bioengineering Conference, Newark, NJ, United States.