Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood

M. P. Weinstein

doi:10.1128/AAC.30.1.187

Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood

M. P. Weinstein

Robert Wood Johnson Medical School (RWJMS), Medicine, Division of Infectious Disease

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The in vitro activity of cefonicid against 60 strains of viridans group streptococci isolated from blood of patients with bacteremia and infective endocarditis was compared with those of cefazolin and penicillin. Cefonicid was less active than cefazolin, and both cephalosporins were less active than penicillin. The MIC₅₀ and MIC₉₀ for the strains tested were 0.06 and 1 μg/ml for penicillin, 0.125 and 8 μg/ml for cefazolin, and 4 and 32 μg/ml for cefonicid.

Original language	English (US)
Pages (from-to)	187-188
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	30
Issue number	1
DOIs	https://doi.org/10.1128/AAC.30.1.187
State	Published - 1986

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.30.1.187

Cite this

@article{2109ee23140240d1bd970f0b942b85f1,

title = "Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood",

abstract = "The in vitro activity of cefonicid against 60 strains of viridans group streptococci isolated from blood of patients with bacteremia and infective endocarditis was compared with those of cefazolin and penicillin. Cefonicid was less active than cefazolin, and both cephalosporins were less active than penicillin. The MIC50 and MIC90 for the strains tested were 0.06 and 1 μg/ml for penicillin, 0.125 and 8 μg/ml for cefazolin, and 4 and 32 μg/ml for cefonicid.",

author = "Weinstein, {M. P.}",

year = "1986",

doi = "10.1128/AAC.30.1.187",

language = "English (US)",

volume = "30",

pages = "187--188",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

TY - JOUR

T1 - Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood

AU - Weinstein, M. P.

PY - 1986

Y1 - 1986

N2 - The in vitro activity of cefonicid against 60 strains of viridans group streptococci isolated from blood of patients with bacteremia and infective endocarditis was compared with those of cefazolin and penicillin. Cefonicid was less active than cefazolin, and both cephalosporins were less active than penicillin. The MIC50 and MIC90 for the strains tested were 0.06 and 1 μg/ml for penicillin, 0.125 and 8 μg/ml for cefazolin, and 4 and 32 μg/ml for cefonicid.

AB - The in vitro activity of cefonicid against 60 strains of viridans group streptococci isolated from blood of patients with bacteremia and infective endocarditis was compared with those of cefazolin and penicillin. Cefonicid was less active than cefazolin, and both cephalosporins were less active than penicillin. The MIC50 and MIC90 for the strains tested were 0.06 and 1 μg/ml for penicillin, 0.125 and 8 μg/ml for cefazolin, and 4 and 32 μg/ml for cefonicid.

UR - http://www.scopus.com/inward/record.url?scp=0022653529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022653529&partnerID=8YFLogxK

U2 - 10.1128/AAC.30.1.187

DO - 10.1128/AAC.30.1.187

M3 - Article

C2 - 3752979

AN - SCOPUS:0022653529

SN - 0066-4804

VL - 30

SP - 187

EP - 188

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 1

ER -

Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this