Comparative killing kinetics of methicillin-resistant staphylococcus aureus by bacitracin or mupirocin

Edward K. Chapnick, Jeremy D. Gradon, Barry Kreiswirth, Larry I. Lutwick, Benjamin C. Schaffer, Thomas D. Schiano, Michael H. Levi

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The in vitro activities of bacitracin and mupirocin were compared for seven different strains of methicillin-resistant Staphylococcus aureus. Six of seven strains showed bacitracin minimum inhibitory concentrations (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs of 0.5 to 2 μg/mL. Time-kill studies revealed 2.6- to 4.5-log reduction in 24 hours with strains susceptible to bacitracin (4 units/mL) and 0 to 2.2 reduction with mupirocin (16 μg/mL). Bacitracin should be considered further for in vivo studies because of enhanced bacteriocidal effect and lower cost (Infect Control Hosp Epidemiol 1996;17:178-180).

Original languageEnglish (US)
Pages (from-to)178-180
Number of pages3
JournalInfection Control and Hospital Epidemiology
Volume17
Issue number3
DOIs
StatePublished - Mar 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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