Comparative metagenomics of microbial communities

Susannah Green Tringe; Christian Von Mering; Arthur Kobayashi; Asaf A. Salamov; Kevin Chen; Hwai W. Chang; Mircea Podar; Jay M. Short; Eric J. Mathur; John C. Detter; Peer Bork; Philip Hugenholtz; Edward M. Rubin

doi:10.1126/science.1107851

Comparative metagenomics of microbial communities

Susannah Green Tringe, Christian Von Mering, Arthur Kobayashi, Asaf A. Salamov, Kevin Chen, Hwai W. Chang, Mircea Podar, Jay M. Short, Eric J. Mathur, John C. Detter, Peer Bork, Philip Hugenholtz, Edward M. Rubin

Research output: Contribution to journal › Article › peer-review

1296 Scopus citations

Abstract

The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

Original language	English (US)
Pages (from-to)	554-557
Number of pages	4
Journal	Science
Volume	308
Issue number	5721
DOIs	https://doi.org/10.1126/science.1107851
State	Published - Apr 22 2005
Externally published	Yes

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10.1126/science.1107851

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@article{61f04548cfd647b59c6598e9418f75a8,

title = "Comparative metagenomics of microbial communities",

abstract = "The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.",

author = "Tringe, {Susannah Green} and {Von Mering}, Christian and Arthur Kobayashi and Salamov, {Asaf A.} and Kevin Chen and Chang, {Hwai W.} and Mircea Podar and Short, {Jay M.} and Mathur, {Eric J.} and Detter, {John C.} and Peer Bork and Philip Hugenholtz and Rubin, {Edward M.}",

year = "2005",

month = apr,

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doi = "10.1126/science.1107851",

language = "English (US)",

volume = "308",

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journal = "Science",

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publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Comparative metagenomics of microbial communities

AU - Tringe, Susannah Green

AU - Von Mering, Christian

AU - Kobayashi, Arthur

AU - Salamov, Asaf A.

AU - Chen, Kevin

AU - Chang, Hwai W.

AU - Podar, Mircea

AU - Short, Jay M.

AU - Mathur, Eric J.

AU - Detter, John C.

AU - Bork, Peer

AU - Hugenholtz, Philip

AU - Rubin, Edward M.

PY - 2005/4/22

Y1 - 2005/4/22

N2 - The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

AB - The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.

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U2 - 10.1126/science.1107851

DO - 10.1126/science.1107851

M3 - Article

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SN - 0036-8075

VL - 308

SP - 554

EP - 557

JO - Science

JF - Science

IS - 5721

ER -

Comparative metagenomics of microbial communities

Abstract

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