TY - JOUR
T1 - Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose
AU - Rodriguez-Tudela, Juan Luis
AU - Gomez-Lopez, Alicia
AU - Arendrup, Maiken C.
AU - Garcia-Effron, Guillermo
AU - Perlin, David S.
AU - Lass-Flörl, Cornelia
AU - Cuenca-Estrella, Manuel
PY - 2010/7
Y1 - 2010/7
N2 - According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.
AB - According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.
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U2 - 10.1128/AAC.00597-10
DO - 10.1128/AAC.00597-10
M3 - Article
C2 - 20479199
AN - SCOPUS:77953754307
SN - 0066-4804
VL - 54
SP - 3056
EP - 3057
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -