Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Juan Luis Rodriguez-Tudela; Alicia Gomez-Lopez; Maiken C. Arendrup; Guillermo Garcia-Effron; David S. Perlin; Cornelia Lass-Flörl; Manuel Cuenca-Estrella

doi:10.1128/AAC.00597-10

Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Juan Luis Rodriguez-Tudela, Alicia Gomez-Lopez, Maiken C. Arendrup, Guillermo Garcia-Effron, David S. Perlin, Cornelia Lass-Flörl, Manuel Cuenca-Estrella

New Jersey Medical School (NJMS), Public Health Research Institute Center

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

Original language	English (US)
Pages (from-to)	3056-3057
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	54
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00597-10
State	Published - Jul 2010

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All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Cite this

Rodriguez-Tudela, J. L., Gomez-Lopez, A., Arendrup, M. C., Garcia-Effron, G., Perlin, D. S., Lass-Flörl, C., & Cuenca-Estrella, M. (2010). Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose. Antimicrobial agents and chemotherapy, 54(7), 3056-3057. https://doi.org/10.1128/AAC.00597-10

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abstract = "According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.",

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Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose. / Rodriguez-Tudela, Juan Luis; Gomez-Lopez, Alicia; Arendrup, Maiken C.; Garcia-Effron, Guillermo; Perlin, David S.; Lass-Flörl, Cornelia; Cuenca-Estrella, Manuel.

In: Antimicrobial agents and chemotherapy, Vol. 54, No. 7, 07.2010, p. 3056-3057.

Research output: Contribution to journal › Article

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10.1128/AAC.00597-10