Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Juan Luis Rodriguez-Tudela, Alicia Gomez-Lopez, Maiken C. Arendrup, Guillermo Garcia-Effron, David S. Perlin, Cornelia Lass-Flörl, Manuel Cuenca-Estrella

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Abstract

According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

Original languageEnglish (US)
Pages (from-to)3056-3057
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number7
DOIs
StatePublished - Jul 2010

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Rodriguez-Tudela, J. L., Gomez-Lopez, A., Arendrup, M. C., Garcia-Effron, G., Perlin, D. S., Lass-Flörl, C., & Cuenca-Estrella, M. (2010). Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose. Antimicrobial agents and chemotherapy, 54(7), 3056-3057. https://doi.org/10.1128/AAC.00597-10