Comparison of different modeling approaches in current lung dosimetry models

W. Hofmann, G. Mainelis, A. Mohamed, I. Balásházy, J. Vaupotic, I. Kobal

Research output: Contribution to journalConference article

19 Scopus citations

Abstract

Theoretical predictions of bronchial doses due to inhaled radon decay products require assumptions about the morphology of the human lung, the physics of particle transport and deposition, the physiology of clearance mechanisms, and the histology of the bronchial epithelium. In this research effort, the effects of different modeling assumptions on deposition, clearance, and cellular dosimetry were investigated in a systematic manner. The resulting range of cellular doses obtained reflects the systematic as well as statistical uncertainty of current dose predictions for lung cancer risk assessment. This comparison of different modeling philosophies suggests that the most critical factors are: inter-subject variability of airway dimensions; inhomogeneity of particle deposition and mucociliary clearance patterns; and distribution, frequency, and relative radiosensitivity of target cells within the bronchial epithelium.

Original languageEnglish (US)
Pages (from-to)S965-S976
JournalEnvironment International
Volume22
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes
EventProceedings of the 1995 6th International Symposium on the Natural Radiation Environment, NRE - Montreal, Can
Duration: Jun 5 1995Jun 9 1995

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)

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