Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth.

M. S. Cannella, F. J. Roisen, T. Ogawa, M. Sugimoto, Robert Ledeen

Research output: Contribution to journalArticle

Abstract

A variety of naturally occurring ganglioside structures were previously shown to be effective agents for inducing neurite outgrowth of primary neurons and neuroblastoma lines. We report here the results of similar experiments with a synthetic epimer of GM3 (epi-GM3) possessing a neuraminidase-resistant beta-ketosidic linkage. This substance was found to enhance neuritogenesis toward two transformed cell lines (neuro-2A, PC-12) and one primary neuronal tissue (dorsal root ganglia). The results indicate that the stereochemistry of the ketoside linkage is not critical and that metabolism of exogenous ganglioside by the treated cells is not involved directly in the neuritogenic phenomenon.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalBrain Research
Volume467
Issue number1
StatePublished - Mar 1 1988
Externally publishedYes

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Gangliosides
Transformed Cell Line
Neuraminidase
Spinal Ganglia
Neuroblastoma
Neurons
Neuronal Outgrowth

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Cannella, M. S., Roisen, F. J., Ogawa, T., Sugimoto, M., & Ledeen, R. (1988). Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth. Brain Research, 467(1), 137-143.
Cannella, M. S. ; Roisen, F. J. ; Ogawa, T. ; Sugimoto, M. ; Ledeen, Robert. / Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth. In: Brain Research. 1988 ; Vol. 467, No. 1. pp. 137-143.
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Cannella, MS, Roisen, FJ, Ogawa, T, Sugimoto, M & Ledeen, R 1988, 'Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth.', Brain Research, vol. 467, no. 1, pp. 137-143.

Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth. / Cannella, M. S.; Roisen, F. J.; Ogawa, T.; Sugimoto, M.; Ledeen, Robert.

In: Brain Research, Vol. 467, No. 1, 01.03.1988, p. 137-143.

Research output: Contribution to journalArticle

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Cannella MS, Roisen FJ, Ogawa T, Sugimoto M, Ledeen R. Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth. Brain Research. 1988 Mar 1;467(1):137-143.