Comparison of epi-GM3 with GM3 and GM1 as stimulators of neurite outgrowth

Michael S. Cannella, Fred J. Roisen, Tomoya Ogawa, Mamoru Sugimoto, Robert W. Ledeen

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

A variety of naturally occurring ganglioside structures were previously shown to be effective agents for inducing neurite outgrowth of primary neurons and neuroblastoma lines. We report here the results of similar experiments with a synthetic epimer of GM3 (epi-GM3) possessing a neuraminidase-resistant β-ketosidic linkage. This substance was found to enhance neuritogenesis toward two transformed cell lines (neuro-2A, PC-12) and one primary neuronal tissue (dorsal root ganglia). The results indicate that the stereochemistry of the ketoside linkage is not critical and that metabolism of exogenous ganglioside by the treated cells is not involved directly in the neuritogenic phenomenon.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalDevelopmental Brain Research
Volume39
Issue number1
DOIs
StatePublished - Mar 1 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Dorsal root ganglion
  • Epi-GM3
  • Ganglioside GM3
  • Neuritogenesis
  • Neuro-2A cell
  • PC-12 cell

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