Changes in compliance of the aorta have been used to diagnose cardiovascular diseases such as atherosclerosis and hypertension. The accuracy of its measurement, however, has not been assessed. To investigate this, mean aortic compliances (C//m calculated from a modified nonlinear Windkessel model are compared with those estimated from stroke-volume/pulse-pressure index (C//v) and from aortic diastolic pressure decay time constant ( tau :C// tau ) in anesthetized dogs during control and during occlusion of the descending thoracic aorta. The model-derived compliance is estimated by an iterative procedure with measured aortic pressure and flow as the input. This compliance (C//m) is used as a standard for comparison. Results show that C// tau is close to C//m, while C//v overestimates. Data suggest that C// tau can be used as a diagnostic index of aortic compliance when a more accurate nonlinear model for obtaining C//m is not available.
|Original language||English (US)|
|Number of pages||2|
|Publication status||Published - Dec 1 1987|
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