Comparison of three rat models of cerebral vasospasm

Ilker Gules, Motoyoshi Satoh, Ben R. Clower, Anil Nanda, John H. Zhang

Research output: Contribution to journalArticle

104 Scopus citations


A substantial number of rat models have been used to research subarachnoid hemorrhage-induced cerebral vasospasm; however, controversy exists regarding which method of selection is appropriate for this species. This study was designed to provide extensive information about the three most popular subarachnoid hemorrhage rat models: the endovascular puncture model, the single-hemorrhage model, and the double-hemorrhage model. In this study, the basilar artery and posterior communicating artery were chosen for histopathological examination and morphometric analysis. Both the endovascular puncture model and single-hemorrhage model developed significant degrees of vasospasm, which were less severe when compared with the double-hemorrhage model. The endovascular puncture model and double-hemorrhage model both developed more vasospasms in the posterior communicating artery than in the basilar artery. The endovascular puncture model has a markedly high mortality rate and high variability in bleeding volume. Overall, the present study showed that the double-hemorrhage model in rats is a more suitable tool with which to investigate mechanism and therapeutic approaches because it accurately correlates with the time courses for vasospasm in humans.

Original languageEnglish (US)
Pages (from-to)H2551-H2559
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 52-6
StatePublished - Dec 1 2002

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


  • Models
  • Rat
  • Subarachnoid hemorrhage
  • Vasospasm

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