Comparison of transdermal penetration through human bioengineered skin, human skin and hairless mouse skin

C. S. Asbill, N. Kim, K. E. Creek, B. B. Michniak

Research output: Contribution to journalArticlepeer-review

Abstract

The utility of a full thickness bioengineered skin equivalent as a screen for transdermal penetration enhancer activity was studied. The human bioengineered skin was cultured at the air-liquid interface for 7-10 days. Azone was tested as a permeation enhancer and caffeine was used as the model drug. A comparison was made between human skin, hairless mouse skin (HMS), and the bioengineered skin. It was found that the skin alternative has slightly higher permeability than the human skin. However, the permeability of the bioengineered skin was much less than that of HMS. The preliminary data indicates that there are similar trends in the penetration of drugs through both the bioengineered skin and human cadaver skin.

Original languageEnglish (US)
Pages (from-to)406-407
Number of pages2
JournalCritical reviews in biomedical engineering
Volume26
Issue number5
StatePublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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