Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance

Shiyan Yu, Nan Gao

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Toll-like receptors (TLRs) are membrane-bound microbial sensors that mediate important host-to-microbe responses. Cell biology aspects of TLR function have been intensively studied in professional immune cells, in particular the macrophages and dendritic cells, but not well explored in other specialized epithelial cell types. The adult intestinal epithelial cells are in close contact with trillions of enteric microbes and engage in lifelong immune surveillance. Mature intestinal epithelial cells, in contrast to immune cells, are highly polarized. Recent studies suggest that distinct mechanisms may govern TLR traffic and compartmentalization in these specialized epithelial cells to establish and maintain precise signaling of individual TLRs. We, using immune cells as references, discuss here the shared and/or unique molecular machineries used by intestinal epithelial cells to control TLR transport, localization, processing, activation, and signaling. A better understanding of these mechanisms will certainly generate important insights into both the mechanism and potential intervention of leading digestive disorders, in particular inflammatory bowel diseases.

Original languageEnglish (US)
Pages (from-to)3343-3353
Number of pages11
JournalCellular and Molecular Life Sciences
Volume72
Issue number17
DOIs
StatePublished - Sep 12 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Keywords

  • Intestinal epithelium
  • Microbe
  • Toll-like receptor
  • Traffic

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