Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China

Liang Chen, Hongyan Hu, Kalyan D. Chavda, Shulong Zhao, Renkun Liu, Hui Liang, Wei Zhang, Xiumei Wang, Michael R. Jacobs, Robert A. Bonomo, Barry N. Kreiswirth

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

We report here the nucleotide sequence of a novel blaKPC-2- harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes bla KPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6′)-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.

Original languageEnglish (US)
Pages (from-to)2422-2425
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number4
DOIs
StatePublished - Apr 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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