Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China

Liang Chen; Hongyan Hu; Kalyan D. Chavda; Shulong Zhao; Renkun Liu; Hui Liang; Wei Zhang; Xiumei Wang; Michael R. Jacobs; Robert A. Bonomo; Barry N. Kreiswirth

doi:10.1128/AAC.02587-13

Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China

Liang Chen, Hongyan Hu, Kalyan D. Chavda, Shulong Zhao, Renkun Liu, Hui Liang, Wei Zhang, Xiumei Wang, Michael R. Jacobs, Robert A. Bonomo, Barry N. Kreiswirth

New Jersey Medical School (NJMS), Public Health Research Institute Center

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We report here the nucleotide sequence of a novel bla_KPC-2- harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes bla _KPC-2, bla_CTX-M-3, and bla_TEM-1; aminoglycoside acetyltransferase gene aac(6′)-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a bla_KPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.

Original language	English (US)
Pages (from-to)	2422-2425
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02587-13
State	Published - Apr 2014

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Chen, L., Hu, H., Chavda, K. D., Zhao, S., Liu, R., Liang, H., Zhang, W., Wang, X., Jacobs, M. R., Bonomo, R. A., & Kreiswirth, B. N. (2014). Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China. Antimicrobial agents and chemotherapy, 58(4), 2422-2425. https://doi.org/10.1128/AAC.02587-13

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title = "Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China",

abstract = "We report here the nucleotide sequence of a novel blaKPC-2- harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes bla KPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6′)-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.",

author = "Liang Chen and Hongyan Hu and Chavda, {Kalyan D.} and Shulong Zhao and Renkun Liu and Hui Liang and Wei Zhang and Xiumei Wang and Jacobs, {Michael R.} and Bonomo, {Robert A.} and Kreiswirth, {Barry N.}",

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AU - Chen, Liang

AU - Hu, Hongyan

AU - Chavda, Kalyan D.

AU - Zhao, Shulong

AU - Liu, Renkun

AU - Liang, Hui

AU - Zhang, Wei

AU - Wang, Xiumei

AU - Jacobs, Michael R.

AU - Bonomo, Robert A.

AU - Kreiswirth, Barry N.

PY - 2014/4

Y1 - 2014/4

N2 - We report here the nucleotide sequence of a novel blaKPC-2- harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes bla KPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6′)-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.

AB - We report here the nucleotide sequence of a novel blaKPC-2- harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes bla KPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6′)-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.

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Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China

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