@inproceedings{9518a4914bb442e6ad085663bb94c33d,

title = "Computation of amplification for systems arising from cellular signaling pathways",

abstract = "A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as H∞ gain. in general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. in contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability.",

keywords = "Gains, Nonlinear systems, Norms, Signaling pathways",

author = "Sontag, {Eduardo D.} and Madalena Chaves",

note = "Funding Information: Email: sontag@math.rutger.sS.upepdoruted in part by NIH Grant R01 GM46383 and NSF Grant CCR-0206789, 2 Email: madalena@math.rutger. sSu.pepodrtued in part by Sanofi-Aventis.",

year = "2005",

doi = "10.3182/20050703-6-cz-1902.02205",

language = "English (US)",

isbn = "008045108X",

series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",

publisher = "IFAC Secretariat",

pages = "7--12",

booktitle = "Proceedings of the 16th IFAC World Congress, IFAC 2005",

address = "Austria",

}