Computation of amplification for systems arising from cellular signaling pathways

Eduardo D. Sontag, Madalena Chaves

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as H gain. in general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. in contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th IFAC World Congress, IFAC 2005
PublisherIFAC Secretariat
Number of pages6
ISBN (Print)008045108X, 9780080451084
StatePublished - 2005

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
ISSN (Print)1474-6670

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering


  • Gains
  • Nonlinear systems
  • Norms
  • Signaling pathways


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