TY - JOUR
T1 - Computer Aided Design and Analysis of Continuous Pharmaceutical Manufacturing Processes
AU - Boukouvala, Fani
AU - Ramachandran, Rohit
AU - Vanarase, Aditya
AU - Muzzio, Fernando J.
AU - Ierapetritou, Marianthi G.
PY - 2011
Y1 - 2011
N2 - Dynamic flowsheet modeling and simulation is a pre-requisite for the design, analysis, control and optimization of an integrated process. Whilst several integrated modeling and simulation tools (commercial and non-commercial) have proven to be effective for fluids processes, their use has been fairly limited for solids processes. The objective of this study is to build a dynamic flowsheet simulation of an integrated continuous downstream pharmaceutical process, using a combination of fundamental and empirical models. Using two cases, the results elucidate (i) the evolution of key particle properties during the transient state (start-up and shutdown), (ii) the effect of changes in process parameters and/or material properties which typically can vary during continuous manufacturing and (iii) the dynamic response and recycle dynamics of an integrated blender and a recirculation tank. Simulation results lend credence to developing a dynamic flowsheet simulation of a fully integrated downstream pharmaceutical process which can be further extended to the general class of solids processes.
AB - Dynamic flowsheet modeling and simulation is a pre-requisite for the design, analysis, control and optimization of an integrated process. Whilst several integrated modeling and simulation tools (commercial and non-commercial) have proven to be effective for fluids processes, their use has been fairly limited for solids processes. The objective of this study is to build a dynamic flowsheet simulation of an integrated continuous downstream pharmaceutical process, using a combination of fundamental and empirical models. Using two cases, the results elucidate (i) the evolution of key particle properties during the transient state (start-up and shutdown), (ii) the effect of changes in process parameters and/or material properties which typically can vary during continuous manufacturing and (iii) the dynamic response and recycle dynamics of an integrated blender and a recirculation tank. Simulation results lend credence to developing a dynamic flowsheet simulation of a fully integrated downstream pharmaceutical process which can be further extended to the general class of solids processes.
KW - Continuous manufacturing
KW - Dynamic flowsheet modeling
KW - Pharmaceutical
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U2 - 10.1016/B978-0-444-53711-9.50044-4
DO - 10.1016/B978-0-444-53711-9.50044-4
M3 - Article
AN - SCOPUS:79958844303
SN - 1570-7946
VL - 29
SP - 216
EP - 220
JO - Computer Aided Chemical Engineering
JF - Computer Aided Chemical Engineering
ER -