Computer Aided Design and Analysis of Continuous Pharmaceutical Manufacturing Processes

Fani Boukouvala, Rohit Ramachandran, Aditya Vanarase, Fernando Muzzio, Marianthi Ierapetritou

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Dynamic flowsheet modeling and simulation is a pre-requisite for the design, analysis, control and optimization of an integrated process. Whilst several integrated modeling and simulation tools (commercial and non-commercial) have proven to be effective for fluids processes, their use has been fairly limited for solids processes. The objective of this study is to build a dynamic flowsheet simulation of an integrated continuous downstream pharmaceutical process, using a combination of fundamental and empirical models. Using two cases, the results elucidate (i) the evolution of key particle properties during the transient state (start-up and shutdown), (ii) the effect of changes in process parameters and/or material properties which typically can vary during continuous manufacturing and (iii) the dynamic response and recycle dynamics of an integrated blender and a recirculation tank. Simulation results lend credence to developing a dynamic flowsheet simulation of a fully integrated downstream pharmaceutical process which can be further extended to the general class of solids processes.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalComputer Aided Chemical Engineering
Volume29
DOIs
StatePublished - Jun 20 2011

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Computer aided analysis
Drug products
Flowcharting
Computer aided design
Pharmaceutical Preparations
Dynamic response
Materials properties
Fluids

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications

Cite this

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Computer Aided Design and Analysis of Continuous Pharmaceutical Manufacturing Processes. / Boukouvala, Fani; Ramachandran, Rohit; Vanarase, Aditya; Muzzio, Fernando; Ierapetritou, Marianthi.

In: Computer Aided Chemical Engineering, Vol. 29, 20.06.2011, p. 216-220.

Research output: Contribution to journalArticle

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