Computer Aided Design and Analysis of Continuous Pharmaceutical Manufacturing Processes

Fani Boukouvala, Rohit Ramachandran, Aditya Vanarase, Fernando J. Muzzio, Marianthi G. Ierapetritou

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Dynamic flowsheet modeling and simulation is a pre-requisite for the design, analysis, control and optimization of an integrated process. Whilst several integrated modeling and simulation tools (commercial and non-commercial) have proven to be effective for fluids processes, their use has been fairly limited for solids processes. The objective of this study is to build a dynamic flowsheet simulation of an integrated continuous downstream pharmaceutical process, using a combination of fundamental and empirical models. Using two cases, the results elucidate (i) the evolution of key particle properties during the transient state (start-up and shutdown), (ii) the effect of changes in process parameters and/or material properties which typically can vary during continuous manufacturing and (iii) the dynamic response and recycle dynamics of an integrated blender and a recirculation tank. Simulation results lend credence to developing a dynamic flowsheet simulation of a fully integrated downstream pharmaceutical process which can be further extended to the general class of solids processes.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalComputer Aided Chemical Engineering
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Computer Science Applications


  • Continuous manufacturing
  • Dynamic flowsheet modeling
  • Pharmaceutical


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