Abstract
Multiple regional myocardial ischemia that leads to depressed left ventricular (LV) function is commonplace. Quantitative analysis of the hemodynamic consequences, however, has been limited. We investigated this aspect using a novel computer model of the cardiovascular system. The model consists of an LV with two ischemic zones (IZs) and a normal zone (NZ), the preload, and the arterial system afterload. The IZ size and activation timing could be altered. Results show that the greater the size and activation asynchronization between NZ and IZ, the more severe the W dysfunction. Increased preload during ischemia improved LV function. This computer model predicts features that agree well with reported experimental observations and is particularly useful for myocardial ischemic function analysis.
Original language | English (US) |
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Pages (from-to) | 371-383 |
Number of pages | 13 |
Journal | Computers in Biology and Medicine |
Volume | 26 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1996 |
All Science Journal Classification (ASJC) codes
- Health Informatics
- Computer Science Applications
Keywords
- Asynchronous activation
- Cardiac efficiency
- Cardiac function
- Computer modeling
- Ejection fraction
- Ischemic zones
- Preload augmentation
- Size of ischemia