Computer modeling of the effects of aortic valve stenosis and arterial system afterload on left ventricular hypertrophy

Ying Zhu, Michele Nanna, John K.J. Li

Research output: Contribution to journalConference article

Abstract

The degree of left ventricular (LV) hypertrophy is generally thought to reflect the severity of aortic stenosis. However the influence of arterial system characteristics is poorly understood. We developed a computer model to investigate the effects of aortic stenosis in combination with various systemic arterial parameters in the development of LV hypertrophy. Data show that an increased peripheral resistance and/or valve resistance, results in an increase in LV wall thickness and mass, while peak systolic wall stress remains constant. Changing arterial compliance to above normal level would not induce changes in wall thickness, while results below normal would cause an increase in wall thickness. When the heart is double loaded, hypertrophic process is aggregated and shows a greater increase in wall thickness.

Original languageEnglish (US)
Pages (from-to)105-106
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 1
StatePublished - Dec 1 1994
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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