Concentration dependent effects of calcium blockade on vessel diameter and microvascular macromolecular clearance.

J. Paul, W. N. Durán

Research output: Contribution to journalArticle

Abstract

The dose-dependents effects of topically applied verapamil (a calcium entry blocker) on vessel diameter and macromolecular clearance (as an index of permeability) were investigated in the hamster cheek pouch. Verapamil at concentrations between 10(-10)M and 10(-7)M produced a gradual and parallel increase in both vessel diameter and in macromolecular clearance. At concentrations between 10(-7)M and 10(-5)M verapamil greatly increased macromolecular transport, but only modestly increased vessel diameter. Our data indicate that low doses of verapamil influence microvascular transport by modulation of flow and associated changes in microvascular pressure, while doses of verapamil greater than or equal to 10(-7)M produce a more direct effect on microvascular permselectivity.

Original languageEnglish (US)
Pages (from-to)441-455
Number of pages15
JournalMicrocirculation, endothelium, and lymphatics
Volume5
Issue number6
StatePublished - Dec 1 1989

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Verapamil
Calcium
Cheek
Cricetinae
Permeability
Pressure

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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