Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8

Dunne Fong; Marion Man-Ying Chan; Wang Ting Hsieh; Joan C. Menninger; David C. Ward

doi:10.1007/BF00207033

Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8

Dunne Fong, Marion Man-Ying Chan, Wang Ting Hsieh, Joan C. Menninger, David C. Ward

School of Arts and Sciences, Center for Collaborative Neuroscience

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Human cathepsin B gene (CTSB) has been mapped to two locations: 8p22 and 13q14. Here we confirm the chromosome 8 assignment by three independent methods: (1) analysis of human-hamster somatic cell hybrid DNA by polymerase chain reaction; (2) comparison of hybridization signals to cathepsin B in interphase nuclei of normal fibroblasts and fibroblasts with a chromosome 8 deletion; and (3) fluorescence in situ hybridization to metaphase spreads using cathepsin B cosmid clones. Our results indicate that human CTSB is located at 8p22-p23.1.

Original language	English (US)
Pages (from-to)	10-12
Number of pages	3
Journal	Human Genetics
Volume	89
Issue number	1
DOIs	https://doi.org/10.1007/BF00207033
State	Published - Apr 1992

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1007/BF00207033

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title = "Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8",

abstract = "Human cathepsin B gene (CTSB) has been mapped to two locations: 8p22 and 13q14. Here we confirm the chromosome 8 assignment by three independent methods: (1) analysis of human-hamster somatic cell hybrid DNA by polymerase chain reaction; (2) comparison of hybridization signals to cathepsin B in interphase nuclei of normal fibroblasts and fibroblasts with a chromosome 8 deletion; and (3) fluorescence in situ hybridization to metaphase spreads using cathepsin B cosmid clones. Our results indicate that human CTSB is located at 8p22-p23.1.",

author = "Dunne Fong and {Man-Ying Chan}, Marion and Hsieh, {Wang Ting} and Menninger, {Joan C.} and Ward, {David C.}",

year = "1992",

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doi = "10.1007/BF00207033",

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AU - Fong, Dunne

AU - Man-Ying Chan, Marion

AU - Hsieh, Wang Ting

AU - Menninger, Joan C.

AU - Ward, David C.

PY - 1992/4

Y1 - 1992/4

N2 - Human cathepsin B gene (CTSB) has been mapped to two locations: 8p22 and 13q14. Here we confirm the chromosome 8 assignment by three independent methods: (1) analysis of human-hamster somatic cell hybrid DNA by polymerase chain reaction; (2) comparison of hybridization signals to cathepsin B in interphase nuclei of normal fibroblasts and fibroblasts with a chromosome 8 deletion; and (3) fluorescence in situ hybridization to metaphase spreads using cathepsin B cosmid clones. Our results indicate that human CTSB is located at 8p22-p23.1.

AB - Human cathepsin B gene (CTSB) has been mapped to two locations: 8p22 and 13q14. Here we confirm the chromosome 8 assignment by three independent methods: (1) analysis of human-hamster somatic cell hybrid DNA by polymerase chain reaction; (2) comparison of hybridization signals to cathepsin B in interphase nuclei of normal fibroblasts and fibroblasts with a chromosome 8 deletion; and (3) fluorescence in situ hybridization to metaphase spreads using cathepsin B cosmid clones. Our results indicate that human CTSB is located at 8p22-p23.1.

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Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8

Abstract

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