Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

Katie C. Bittner, Christine Grienberger, Sachin P. Vaidya, Aaron D. Milstein, John J. Macklin, Junghyup Suh, Susumu Tonegawa, Jeffrey C. Magee

Research output: Contribution to journalArticlepeer-review

230 Scopus citations

Abstract

Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps.

Original languageEnglish (US)
Pages (from-to)1133-1142
Number of pages10
JournalNature Neuroscience
Volume18
Issue number8
DOIs
StatePublished - Aug 30 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons'. Together they form a unique fingerprint.

Cite this